For a calendar of Oktoberfest and Craft Brew Festivals, check this out.
Most of the craft breweries in this guide offer tours of their own breweries, but there are also independently operated bus tours of multiple breweries that include all-inclusive tastings and tours.
Leave the driving to them. For details, click on the links.
Punta Gorda Brew Tours, Punta Gorda. Tour breweries from Fort Myers north to Sarasota by bus.
Southwest Florida Ale Trail (Self-guided). 17 participating breweries in Lee, Collier, & Charlotte counties.
Tallahassee Brew Bus, 3305 Capital Cir NE, Tallahassee. Tours of Tallahassee or Apalachicola breweries.
Tampa Bay Brewery Tours from Downtown St Pete, St Pete Beach and Treasure Island.
Tampa Bay Brewery Tours from Clearwater Beach